Orioles vs. Guardians Odds & Betting Predictions - April 16, 2026

Orioles at Guardians

10:10 pm • CLEG
2 - 4
Starting Pitchers
pitcherteameraw-l
Parker Messick logoP.MessickCleveland Guardians logo1.053-0
Shane Baz logoS.BazBaltimore Orioles logo4.910-2

Orioles at Guardians Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Orioles
10-10
+1.5
+1.5-194
o8-102
+115
Guardians
11-10
u8
-1.5+158
u8-114
-136
location pinThursday 10:10 p.m.
April 16, 2026
Progressive FieldCleveland
Orioles vs. Guardians Expert Picks
Sir Lockselot
Sir Lockselot
Last 30d: 20-51-0 (-20.2u)
BAL +113
3u
📚Onyx
Austin Pendergrass
Austin Pendergrass
Last 30d: 33-35-0 (-3.9u)
CLE -130
0.38u
A.Martinez o0.5 Hits-175
1u
Ryan Minion
Ryan Minion
Last 30d: 219-278-4 (-19.2u)
Under 0.5 (1st Inn)-135
$1.35
Under 4.5 (F5)-135
$1.00
Cam Is Money
Cam Is Money
Last 30d: 107-78-4 (+26.1u)
S.Kwan o1.5 Hits + Runs + RBIs-120
0.83u
Scott Rickenbach
Scott Rickenbach
Last 30d: 99-108-4 (-16.9u)
CLE -125
0.8u
Kyle Murray
Kyle Murray
Last 30d: 64-129-4 (-26.8u)
CLE -125
1u
P.Messick o5.5 Ks-130
1u
Ryan Minion
Ryan Minion
Last 30d: 219-278-4 (-19.2u)
J.Ramirez o1.5 Total Bases+118
$1.18
Frank Ammirante
Frank Ammirante
Last 30d: 193-246-13 (-16.5u)
J.Ramirez o0.5 HR+564
0.56u
Under 0.5 (1st Inn)-125
1.25u
Under 4.5 (F5)-130
1u
Under 8-110
1u
Brian Bitler
Brian Bitler
Last 30d: 64-66-2 (-13.1u)
BAL +110
3u
Doug Ziefel
Doug Ziefel
Last 30d: 277-371-21 (-22.1u)
P.Messick o16.5 Outs-105
0.5u
S.Baz u4.5 Ks+120
0.42u
Sandy Plashkes
Sandy Plashkes
Last 30d: 126-112-6 (+11.2u)
C.DeLauter o1.5 Hits + Runs + RBIs-120
1.2u
RoyalsProps
RoyalsProps
Last 30d: 62-53-5 (+3.7u)
C.DeLauter o1.5 Hits + Runs + RBIs-105
1.05u
Sean Zerillo
Sean Zerillo
Last 30d: 147-147-8 (-10.7u)
Over 8-105
0.53u
Bet to 8.5 (+100)
Matt Trollo
Matt Trollo
Last 30d: 34-47-6 (-9.4u)
CLE -124 (F5)
0.5u
(FD) See Thursday's article. (There are some better numbers out there, but neither DK, nor B365 have it up yet and I'm posting what I got, Wouldn't want to risk losing this line, but wouldn't play it any worse.)
Nick Martin
Nick Martin
Last 30d: 73-115-0 (-7.8u)
BAL +100
0.5u

Orioles vs. Guardians Previews & Analysis

  • Orioles vs Guardians: The F5 Bet to Make on Thursday article feature image

    Orioles vs Guardians: The F5 Bet to Make on Thursday

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    Apr 16, 2026 UTC
  • MLB Best Bets for Thursday article feature image

    MLB Best Bets for Thursday

    Action Network Staff
    Apr 16, 2026 UTC
  • Zerillo's Opening Pitch for Thursday article feature image

    Zerillo's Opening Pitch for Thursday

    Sean Zerillo
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Prop Odds Comparison

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Line Movement Tracker

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Orioles vs. Guardians Public Betting Percentages

Away Logo

Orioles

Public

22%

Bets%

78%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Guardians
12-96-26-74-38-6
Orioles
8-125-73-56-82-4

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Guardians
10-113-57-63-47-7
Orioles
11-97-54-47-74-2

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Guardians
11-105-36-74-37-7
Orioles
10-106-64-48-62-4

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Apr 15th@STLL 3-5-U 9STL -112
Apr 14th@STLL 5-6-1.5 LO 9STL -120
Apr 13th@STLW 9-3-1.5 WO 8CLE -120
Apr 12th@ATLL 1-13+1.5 LO 7.5ATL +164
Apr 11th@ATLW 6-0-1.5 WU 8CLE -102

Orioles vs. Guardians Injury Updates

Orioles Injuries

  • Adley Rutschman
    C

    Adley Rutschman has been scratched Saturday.

    Out

  • Heston Kjerstad
    LF

    Kjerstad is out with hamstring

    Out

  • Jordan Westburg
    3B

    Westburg is out with elbow

    Out

  • Jackson Holliday
    2B

    Holliday is out with hand

    Out

Guardians Injuries

    Orioles vs. Guardians Box Score
    Orioles Player Stats
    Projected
    PITCHERPCIPKER
    Shane Baz logoRS.Baz, P99664
    Cameron Foster logoRC.Foster, P421.230
    Tyler Wells logoRT.Wells, P60.110
    HITTERSH-ABRHRRBI
    Taylor Ward logo1T.Ward, LF1-3000
    Gunnar Henderson logo2G.Henderson, DH0-3001
    Pete Alonso logo3P.Alonso, 1B1-4001
    Johnathan Rodriguez logo4J.Rodriguez, RF0-3000
    Colton Cowser logo4C.Cowser, PH0-1000
    Samuel Basallo logo5S.Basallo, C0-4000
    Jeremiah Jackson logo6J.Jackson, 2B0-3000
    Coby Mayo logo7C.Mayo, 3B0-3000
    Leody Taveras logo8L.Taveras, CF1-2100
    Blaze Alexander logo9B.Alexander, SS1-3100
    Guardians Player Stats
    Projected
    PITCHERPCIPKER
    Parker Messick logoLP.Messick, P112892
    Cade Smith logoRC.Smith, P19100
    HITTERSH-ABRHRRBI
    Steven Kwan logo1S.Kwan, CF2-4001
    Chase DeLauter logo2C.DeLauter, DH0-3100
    Jose Ramirez logo3J.Ramirez, 3B2-3212
    Kyle Manzardo logo4K.Manzardo, 1B1-3000
    George Valera logo5G.Valera, RF2-4001
    Angel Martinez logo6A.Martinez, LF0-4000
    Juan Brito logo7J.Brito, 2B0-3000
    Austin Hedges logo8A.Hedges, C0-4000
    Brayan Rocchio logo9B.Rocchio, SS1-3100

    Orioles vs. Guardians Odds Comparison

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    Orioles at Guardians Team Totals

    MatchupOverUnder
    Orioles
    10-10
    N/A
    N/A
    Guardians
    11-10
    N/A
    N/A