| E. Hyndman | MID | Out indefinitely | Broken Leg | Broken Leg | Aug 27 |
| Tyler David Wolff | A | Doubtful | Tyler Wolff is Doubtful with Shoulder injury. | Wolff is doubtful with shoulder | Apr 18 |
| E. Rigoni | A | Out | Hamstring | Hamstring | Mar 17 |
| Bojan | A | Out indefinitely | Hamstring | Hamstring | Oct 16 |
| V. Wanyama | MID | Out indefinitely | Knee Injury | Knee Injury | Jan 29 |
| D. Mihailovic | MID | Out | Djordje Mihailovic is expected to return Early May 2026 from Knock injury. | Mihailovic is out with knock injury | Apr 11 |
| C. Fuchs | DEF | Out indefinitely | Groin/Pelvis Injury | Groin/Pelvis Injury | Sep 14 |
| Bastian Schweinsteiger | MID | Out indefinitely | Knock | Knock | Oct 13 |
| R. Berič | A | Out indefinitely | Thigh Muscle Strain | Thigh Muscle Strain | Dec 2 |
| N. Gaitán | MID | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Sep 11 |
| Álvaro Medrán Just | MID | Out indefinitely | Back Injury | Back Injury | May 3 |
| Christopher Matthew Mueller | MID | Out | Chris Mueller is expected to return Early May 2026 from Knock injury. | Mueller is out with knock injury | Apr 18 |
| M. Navarro | MID | Out | Miguel Navarro is expected to return Late May 2026 from Hamstring Injury. | Navarro is out with hamstring | Apr 18 |
| G. Giménez | MID | Out | Gastón Giménez is expected to return Mid May 2026 from Muscle injury. | Gimenez is out with muscle | Apr 14 |
| V. Bezerra | A | Out indefinitely | None | Bezerra is injured | Aug 25 |
| S. Nicholson | MID | Out indefinitely | None | Nicholson is injured | Oct 21 |
| Jack Price | midfielder | Out indefinitely | None | Price is injured | Aug 25 |
| B. Smith | DEF | Out indefinitely | Hip/Thigh Injury | Hip/Thigh Injury | Jan 12 |
| C. Benteke | A | Out indefinitely | Ankle/Foot Injury | Ankle/Foot Injury | Jun 7 |
| W. Rooney | A | Out indefinitely | Knee Injury | Knee Injury | May 28 |
| G. Cameron | DEF | Out | Concussion | Concussion | Dec 1 |
| M. Deplagne | DEF | Out indefinitely | Knock | Knock | Jun 4 |
| S. de Jong | MID | Out indefinitely | Calf Muscle Strain | Calf Muscle Strain | Jun 5 |
| C. Stanko | MID | Out indefinitely | Knee Injury | Knee Injury | Jan 16 |
| O. Nwobodo | MID | Out | Obinna Nwobodo is expected to return Mid May 2026 from Leg injury. | Nwobodo is out with leg | Apr 18 |
| F. Quignón | MID | Doubtful | None | Quignon is doubtful | Nov 10 |
| Ifunanyachi Achara | A | Out indefinitely | None | Achara is injured | Aug 25 |
| Douglas Costa | MID | Out indefinitely | Metatarsal Fracture | Metatarsal Fracture | Feb 10 |
| R. Alessandrini | MID | Out indefinitely | MCL Knee Ligament Injury | MCL Knee Ligament Injury | Mar 6 |
| N. DePuy | DEF | Out indefinitely | None | DePuy is injured | Aug 25 |
| Vadim Demidov | DEF | Out indefinitely | Hamstring | Hamstring | Mar 9 |
| Brou Benjamin Angoua | DEF | Out indefinitely | Knock | Knock | Mar 19 |
| Wilfrid Jaures Kaptoum | MID | Out indefinitely | Hamstring | Hamstring | Oct 27 |
| DeJuan Jones | defender | Out | DeJuan Jones is expected to return Late December 2026 from Achilles tendon injury. | Jones is out with achilles | Apr 1 |
| A. Reyes | DEF | Out | Andrés Reyes is expected to return Mid May 2026 from Muscle injury. | Reyes is out with muscle | Apr 18 |
| Omir Fernandez | midfielder | Out | Omir Fernandez is expected to return Early June 2026 from Foot injury. | Fernandez is out with foot | Feb 15 |
| W. Cartagena | MID | Out | Wilder Cartagena is expected to return Mid May 2026 from Thigh injury. | Cartagena is out with thigh | Apr 18 |
| A. Perea | MID | Out | Andrés Perea is expected to return Mid May 2026 from Leg injury. | Perea is out with leg | Apr 18 |
| Antônio Carlos | DEF | Suspended | Antônio Carlos is serving a suspension for Red card. | Carlos is suspended with red card | Mar 2 |
| Sergio Santos | A | Out | Sergio Santos is expected to return Mid May 2026 from Calf injury. | Santos is out with calf | Apr 11 |
| D. Ayala | MID | Out | David Ayala is expected to return Mid May 2026 from Muscle injury. | Ayala is out with muscle | Apr 18 |
| J. Mosquera | A | Out | Juan Mosquera is expected to return Mid May 2026 from Foot injury. | Mosquera is out with foot | Apr 11 |
| Zac McGraw | defender | Out | Zac McGraw is expected to return Early May 2026 from Back injury. | McGraw is out with back | Feb 14 |
| Bobby Shou Wood | A | Out indefinitely | Knee Injury | Knee Injury | Jun 10 |
| Justen Glad | DEF | Doubtful | Justen Glad is Doubtful with Knock injury. | Glad is doubtful with knock injury | Apr 18 |
| Stephen Obayan Sunday | MID | Out indefinitely | Suspended | Suspended | Feb 24 |
| A. Julio | MID | Out | Anderson Julio is expected to return Early May 2026 from Leg injury. | Julio is out with leg | Mar 14 |
| Jackson Yueill | MID | Doubtful | Jackson Yueill is Doubtful with Knock injury. | Yueill is doubtful with knock injury | Apr 18 |
| M. López | DEF | Out indefinitely | Knock | Knock | Aug 28 |
| R. Walter | MID | Out | Ankle Ligaments | Ankle Ligaments | Oct 14 |
| N. Radoja | MID | Out indefinitely | Hamstring | Hamstring | Mar 7 |
| N. Isimat-Mirin | DEF | Out | Knee Injury | Knee Injury | Feb 15 |
| K. Ford | DEF | Out indefinitely | None | Ford is injured | Aug 25 |
| C. Salcedo | DEF | Out | Foot Injury | Foot Injury | Nov 29 |
| Russell Teibert | MID | Out indefinitely | None | Teibert is injured | Aug 25 |
