The Baltimore Orioles host the San Francisco Giants on April 10, 2026. First pitch from Oriole Park at Camden Yards is scheduled for 7:15 p.m. EDT. The game will be broadcast on Apple TV+.
The – are favored by -125 on the moneyline and by – on the run line. The – are +105 on the moneyline and – on the run line. The total is set at 8.5 runs.
Find my MLB picks and Giants vs Orioles prediction below, as well as probable pitchers, weather report, and more.
Giants vs Orioles Prediction, Picks
- Giants vs Orioles Pick: Colton Cowser Over 1.5 Total Bases (+220, FanDuel)
My Giants vs Orioles best bet is on Colton Cowser's total base prop. Make sure to find the best odds by checking our live MLB odds page.
Giants vs Orioles Odds, Run Line, and Total
| Giants Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -194 | 8.5 -110o / -110u | +108 |
| Orioles Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +160 | 8.5 -110o / -110u | -126 |
- Giants vs Orioles spread: Giants +1.5 (-194), Orioles -1.5 (+160)
- Giants vs Orioles over/under: 8.5 (-110o / -110u)
- Giants vs Orioles moneyline: Giants +108, Orioles -126
Giants vs Orioles MLB Prop Pick
Baltimore Orioles: Colton Cowser Over 1.5 Total Bases
Colton Cowser has had a slow start to the season, but I think he bounces back on Friday.
Cowser has a good matchup against the Giants' starting pitcher, Landen Roupp, who has started the season well, but I’m expecting some regression from him.
Cowser is a platoon-specific hitter. You want to back him against right-handed pitching. He’s about a 5% above-average hitter against righties but about 15% below-average against lefties.
Roupp is a right-handed sinkerballer who, as a result, runs a high ground-ball rate. But he’s running a 63% ground-ball rate through his first two starts this season, and I fully expect that to regress.
Meanwhile, Cowser is due for some positive regression. He has a 64-point difference between his Expected Batting Average and actual Batting Average, and an 113-point difference between his Expected Slugging and actual Slugging.
Roupp throws three other pitches to lefties: a changeup, a curveball, and a cutter. Cowser hits all three pitches well.
Ultimately, we’re getting a solid price on Cowser because of his slow start and lack of name recognition.
Pick: Colton Cowser Over 1.5 Total Bases (+220, FanDuel)
